Subrata Deb (Larkin U):

Simulation of Physicochemical and Pharmacokinetic Properties of Vitamin D3: Potential Interaction with Psychiatric Drugs

Vitamin D3 is an essential micronutrient, either biosynthesized in human skin or absorbed from diet and health supplements. Multiple hydroxylation reactions in several tissues, including liver and small intestine, produce different forms of vitamin D3. Low serum vitamin D levels may origin from differential absorption following supplementation or altered metabolism. The objective of the present study was to estimate the physicochemical and pharmacokinetic properties of vitamin D3 derivatives in silico, as well as their potential interactions with psychiatric medications. The GastroPlus simulation platform identified that the majority of the vitamin D3 derivatives are lipophilic (log P >5) with poor water solubility, which was reflected in their relatively poor predicted bioavailability. Following drug-vitamin D3 interaction simulations with commonly used typical antipsychotics, atypical antipsychotics, antidepressants, and anticonvulsants, only carbamazepine and phenytoin demonstrated potential interactions with vitamin D3 metabolism. Understanding vitamin D3 disposition and its related drug interactions may help explain its low serum levels.