Education and Training

B. Pharm | Kwame Nkrumah University of Science and Technology | Kumasi, Ghana

M. Phil | Kwame Nkrumah University of Science and Technology | Kumasi, Ghana

Ph.D. | University of Missouri – Kansas City | Kansas City, MO

Post-Doctoral | University of Missouri – Kansas City | Kansas City, MO

Teaching Interests

Dr. Mamani’s teaching interests include medicinal chemistry, pharmacokinetics, and pharmaceutics.

Scholarly Interests

Dr. Mamani’s research focuses on the design and development of peptides for targeted drug delivery and as therapeutic agents for important targets such the PD-1/PD-L1 immune checkpoint pathway. He leverages techniques in medicinal chemistry, analytical chemistry, and molecular biology to optimize peptide potency, stability and pharmacokinetic profiles. A key area of his work involved the use of multimerization strategies to create multivalent anti-PD-L1 peptide inhibitors with enhanced activity.

Currently, Dr. Mamani is exploring innovative approaches to target and treat immunologically ‘cold’ tumors. He aims to develop a multivalent bispecific peptide platform capable of simultaneously blocking multiple immune checkpoints within the tumor microenvironment. Additionally, he is investigating the co-delivery of immune checkpoint inhibitors, such as anti-PD-L1 inhibitors, alongside immunoadjuvants to enhance the efficacy of cancer immunotherapy.