Larkin University 1/7/2020 – for immediate release
Short-Term Acute Exercise Preconditioning Reduces Neurovascular Injury After Stroke-New Research from the College of Pharmacy published in Translational Stroke Research.
Physical exercise is known to reduce cardiovascular risk but its role in ischemic stroke is not clear. In this study a research team lead by Dr. Sherif Hafez from LU’s Department of Pharmaceutical Sciences in the College of Pharmacy and Dr. David C. Hess from Augusta University in Georgia was testing the hypothesis that short-term acute exercise can provide “immediate neuroprotection” and improve stroke outcomes through induced eNOS activation. Translational Stroke Research published by Springer is a leading translational research journal with a distinguished editorial board made up of leading stroke researchers and physicians from North America, Europe, and Asia. The journal publishes research in stroke and stroke related areas relevant to both basic scientists and physicians, including but not restricted to neuroscientists, vascular biologists, neurologists, neuroimagers, and neurosurgeons. In the study acute exercise significantly reduced infarct size, edema, and improved functional outcomes, and significantly increased the expression of peNOS and pAMPK in the brain, cerebral vessels, and aorta. eNOS inhibition abolished the exercise-induced improvement in outcomes. Short-term acute preconditioning exercise reduced the neurovascular injury and improved functional outcomes after stroke through eNOS activation.
Congratulations, Dr. Hafez, on this exiting and important result!
See the following link for more information:
https://link.springer.com/artic…/10.1007/s12975-019-00767-y4
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