Research Profile

Dr Edwards uses structural biology (mostly X-ray crystallography, but including EM and NMR) to study the structure and function of a variety of proteins.  He studies RNA binding proteins in development and disease and has recently focused on RNA binding proteins from RNA viruses. Another focus is in investigating protein-protein interactions involved in the control of cancer.

73 publications, >4,000 citations, H-index = 33

Selected recent publications:

The cryoEM structure of the Hendra henipavirus nucleoprotein reveals insights into paramyxoviral nucleocapsid architectures. Tim C Passchier, Joshua BR White, Daniel P Maskell, Matthew J Byrne, Neil A Ranson, Thomas A Edwards, John N Barr (2024). Scientific Reports DOI https://doi.org/10.1038/s41598-024-58243-z

Understanding β-strand mediated protein–protein interactions: tuning binding behaviour of intrinsically disordered sequences by backbone modification. Emma E Cawood, Emily Baker, Thomas A Edwards, Derek N Woolfson, Theodoros K Karamanos, Andrew J Wilson (2024). Chemical Science. DOI: 10.1039/D4SC02240H

The native orthobunyavirus ribonucleoprotein possesses a helical architecture. Francis R Hopkins, Beatriz Álvarez-Rodríguez, George R Heath, Kyriakoulla Panayi, Samantha Hover, Thomas A Edwards, John N Barr, Juan Fontana (2022). MBio 13.4 e01405-22. DOI: https://doi.org/10.1038/s41467-021-24316-0

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site. KZ Haza, HL Martin, A Rao, AL Turner, SE Saunders, B Petersen, C Tiede, Kevin Tipping, Anna A Tang, Modupe Ajayi, Thomas Taylor, Maia Harvey, Keri M Fishwick, Thomas L Adams, Thembaninkosi G Gaule, Chi H Trinh, Matthew Johnson, Alexander L Breeze, Thomas A Edwards, Michael J McPherson, Darren C Tomlinson (2021). Nature Communications 12 (1), 1-15. https://doi.org/10.1038/s41467-021-24316-0

Selective Affimers Recognise the BCL‐2 Family Proteins BCL‐xL and MCL‐1 through Noncanonical Structural Motifs. JA Miles, F Hobor, CH Trinh, J Taylor, C Tiede, PR Rowell, BR Jackson, Fatima A Nadat, Pallavi Ramsahye, Hannah F Kyle, Basile IM Wicky, Jane Clarke, Darren C Tomlinson, Andrew J Wilson, Thomas A Edwards (2021). ChemBioChem 22 (1), 232-240. https://doi.org/10.1002/cbic.202000585

Structure of the 70S ribosome from the human pathogen acinetobacter baumannii in complex with clinically relevant antibiotics. D Nicholson, TA Edwards, AJ O’Neill, NA Ranson (2020). Structure 28 (10), 1087-1100. e3.

The structure of the human respiratory syncytial virus M2-1 protein bound to the interaction domain of the phosphoprotein P defines the orientation of the complex. M Selvaraj, K Yegambaram, EJAA Todd, CA Richard, RL Dods, Georgia M Pangratiou, Chi H Trinh, Sophie L Moul, James C Murphy, Jamel Mankouri, Jean-François Éléouët, John N Barr, Thomas A Edwards (2018). mBio 9 (6), e01554-18.

Hypoxia inducible factor (HIF) as a model for studying inhibition of protein–protein interactions. GM Burslem, HF Kyle, A Nelson, TA Edwards, AJ Wilson (2017). Chemical Science 8 (6), 4188-4202.

ABC-F proteins mediate antibiotic resistance through ribosomal protection. LKR Sharkey, TA Edwards, AJ O’Neill (2016). mBio 7 (2), e01975-15.

Selective and potent proteomimetic inhibitors of intracellular protein–protein interactions. A Barnard, K Long, HL Martin, JA Miles, TA Edwards, DC Tomlinson, Andrew Macdonald, Andrew J Wilson (2015). Angewandte Chemie 127 (10), 3003-3008.

Crystal structure of the essential transcription antiterminator M2-1 protein of human respiratory syncytial virus and implications of its phosphorylation. SJ Tanner, A Ariza, CA Richard, HF Kyle, RL Dods, ML Blondot, W Wu, José Trincão, Chi H Trinh, Julian A Hiscox, Miles W Carroll, Nigel J Silman, Jean-François Eléouët, Thomas A Edwards, John N Barr (2014). Proceedings of the National Academy of Sciences 111 (4), 1580-1585.

 Full publication list:

‪Thomas A. Edwards – ‪Google Scholar